by: Charly TacachoPosted on:

EL CONSUMO DE ANTIBIÓTICOS PODRÍA AFECTAR A TU RENDIMIENTO

El microbioma intestinal puede afectar varios aspectos tanto del comportamiento como de la fisiología, incluida la capacidad de ejercicio, pero rara vez se han estudiado los efectos sobre el ejercicio voluntario.

Los antibióticos orales reducen el comportamiento de ejercicio voluntario en ratones atléticos

En un reciente estudio (https://doi.org/10.1016/j.beproc.2022.104650)

  1. Se criaron selectivamente líneas replicadas de ratones High Runner para el ejercicio voluntario.
  2. Se utilizó un cóctel de antibióticos de amplio espectro para reducir en gran medida el microbioma intestinal.
  3. Los antibióticos redujeron el comportamiento de funcionamiento de las ruedas, especialmente en los High Runners.
  4. Los antibióticos redujeron la duración del funcionamiento de las ruedas, pero no la velocidad.
  5. Los antibióticos no causaron enfermedad, según la masa corporal, el consumo de alimentos y agua.
EXPERIMENTO

Se estudió 4 líneas de ratones hembras High Runner (HR) replicadas para el ejercicio voluntario y se compararon con 4 líneas de control (C) no seleccionadas.

Los ratones HR y C difieren en varios rasgos que probablemente interactúan con el microbioma intestinal, incluida una mayor distancia diaria para correr, temperaturas corporales al correr, actividad física espontánea cuando se alojan sin ruedas y consumo de alimentos.

SUMINISTRO DE ANTIBIÓTICOS

Después de dos semanas de correr, para alcanzar una meseta estable en corridas diarias, a los ratones se les administraron antibióticos de amplio espectro durante 10 días.

El tratamiento con antibióticos provocó una reducción significativa en la distancia diaria de carrera en la rueda en los ratones HR (−21 %), pero no en los ratones C.

Figura1: Funcionamiento medio diario de la rueda (revoluciones por 23 h) a lo largo 
del experimento. Los valores se calcularon tomando las medias simples de las 4 
líneas HR y las 4 líneas C para cada día individual y luego promediando esos valores 
para obtener el promedio de las líneas HR y C. Los datos se truncaron los días 8, 14 
y 25 (~20 h) cuando se cambiaban las botellas de agua. Los corchetes indican los días 
que se utilizaron en los análisis estadísticos.

Los antibióticos no afectaron la masa corporal o el consumo de alimentos en ratones HR o C, y no observamos comportamiento de enfermedad . 

El funcionamiento de la rueda de los ratones HR no se recuperó durante los 12 días posteriores al cese de los antibióticos. La disminución del funcionamiento de la rueda en los ratones HR pero no en los C, sin efectos secundarios negativos aparentes de los antibióticos, sugiere que el microbioma HR es un componente importante de su fenotipo de alto funcionamiento.

Los cócteles de antibióticos anteriores que incluían ampicilina , estreptomicina y neomicina en combinación con otros antibióticos han demostrado una disminución exitosa o el agotamiento de las colonias anaerobias.

La reducción del microbioma intestinal podría haber alterado la motivación y/o la capacidad para el ejercicio sostenido con apoyo aeróbico, los cuales son más altos en los ratones HR en relación con los ratones C.

Los antibióticos redujeron el consumo de alimentos en los ratones HR pero no en los C. Con la masa corporal como covariable, tanto los ratones HR como los C tuvieron un aumento significativo en el consumo de agua durante el tratamiento con antibióticos en comparación con los valores previos al antibiótico.

Efectos del tratamiento con antibióticos de amplio espectro o el estado libre de gérmenes sobre el rendimiento de resistencia y las adaptaciones al ejercicio en ratones

Se desconoce hasta qué punto los microbios intestinales son responsables de las adaptaciones fisiológicas al entrenamiento físico. En otro estudio reciente (DOI: 10.1249/MSS.0000000000003051) se intenta evaluar como el ejercicio de resistencia altera el microbioma intestinal.

PROPÓSITO

El propósito de estos experimentos fue determinar el papel de los microbios intestinales en el rendimiento y la adaptación muscular a seis semanas de carrera voluntaria sobre ruedas (VWR) en ratones.

MÉTODO

Eliminamos los microbios con un tratamiento con antibióticos de amplio espectro (ABX) y usamos ratones libres de gérmenes (GF) para determinar los efectos sobre las adaptaciones a VWR.

Se asignaron ratones macho y hembra C57Bl/6 (n = 56) a VWR diario a condiciones sedentarias. Después de la intervención, se evaluaron la resistencia a la cinta rodante y la tolerancia a la glucosa, y los tejidos del gastrocnemio y el sóleo. Se recolectaron y analizaron para determinar la actividad de la enzima citrato sintasa (CS) y la expresión de genes sensibles al entrenamiento físico.

RESULTADOS

El tratamiento con anfibióticos de alto espectro y el estado de los ratones libres de gérmenes (GF) redujeron el comportamiento de carrera voluntaria sobre ruedas (VWR), pero no afectaron las adaptaciones inducidas por VWR en la capacidad de resistencia, la actividad de la enzima citrato sintasa o la expresión de genes metabólicos musculares.

Sin embargo, el estado de GF redujo la capacidad de resistencia. Estos datos indicaron que la reducción de microbios en la edad adulta no inhibe las adaptaciones del entrenamiento de resistencia en ratones C57Bl/6.

CONCLUSIÓN

La conclusión práctica, según Hutchinson y sus colaboradores, es que si necesitas tomar antibióticos antes de una competencia importante, es poco probable que afecte tus adaptaciones de entrenamiento o su rendimiento. Creo que es una posición razonable y tranquilizadora, teniendo en cuenta todas las incertidumbres inherentes a la aplicación de estudios con ratones al comportamiento humano .

 Por lo general, significa que es necesario realizar más investigaciones para averiguar si los hallazgos son reproducibles y aplicables a las otras condiciones. Lamentablemente, en la mayoría de los casos, la atención o el tratamiento no están disponibles de la noche a la mañana. Sin embargo, la (sobre)venta a menudo es necesaria para atraer nuevas subvenciones para la investigación. Dice el Dr. e Investigador Vootele Voikar, a cerca del uso de ratones en experimentos para la salud humana. 

Pero es el aparente cambio en la motivación para hacer ejercicio lo que realmente intriga. ¿Hay algo allí que ayude a explicar quién de nosotros termina como High Runner? Si es así, ¿podemos manipularlo? Es fácil ver cómo podría quedar atrapado en el entusiasmo por los posibles nuevos suplementos probióticos que alteran no solo su capacidad sino también su deseo de hacer ejercicio. Garland, en un comunicado de prensa de UC Riverside , insinúa esa posibilidad. Pero su consejo, por ahora, está adecuadamente fundamentado en la realidad actual. Si desea un microbioma saludable, sugiere, debe comer una dieta balanceada y hacer ejercicio regularmente.

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